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曾翠華教授

 

曾翠華 教授

 
  Tsui-Hwa Tseng   
 

聯絡方式: 04-24730022 轉 12230      

E-mail :  tht@csmu.edu.tw 

辦公室:正心樓1256D

 台大藥研所畢,中山醫學大學生化科所教授、科主任,中山醫學大學健康管理學院應用化學系教授,中山醫學大學總務長及環境與安全衛生中心主任,獲87年度國科會甲種獎助,獲88年度國科會甲種獎助

 授課領域

   分析化學、藥物化學

  研究領域

  1.保健天然物成份及活性之開發研究。
  2.抗癌藥物之分子機制研究。
  3.心血管疾病預防之生化藥理研究。
  4.環境致癌預防之生化藥理研究。 

 相關研究著作

A. 論文期刊 (SCIorSSCI)

 

1

Tsui-Hwa Tseng, Ming-Hsien Chien, Wea-Lung Lin, Yu-Ching Wen, Jyh-Ming Chow, Chi-Kuan Chen, Tsang-Chih Kuo, Wei-Jiunn Lee (2016).  Proliferation and Tumor Growth by Apigenin Through Induction of G2/M Arrest and Histone H3 Acetylation-mediated p21WAF1/CIP1 Expression.  Environmental Toxicology DOI 10.1002/tox.  

2

Lin WL, Lai DY, Lee YJ, Chen NF, Tseng TH* (2015). Antitumor progression potential of morusin suppressing STAT3 and NFkB in human hepatoma SK-Hep-1 cells. Toxicol Letters 232:490-498  

3

Wei-Jiunn Lee,  Michael Hsiao, Junn-Liang Chang,  Shun-Fa Yang, Tsui-Hwa Tseng · Chao-Wen Cheng, ·Jyh-Ming Chow, Ke-Hsun Lin, Yung-Wei Lin (2015) Quercetin induces mitochondrial‑derived apoptosis via reactive oxygen species‑mediated ERK activation in HL‑60 leukemia cells and xenograft. Arch Toxicol  89:1103–1117  

4

Lin WL, Wang SM, Ho YJ, Kuo HC, Lee YJ, Tseng TH* (2014) Ethyl acetate extract of Wedelia chinesis inhibits tert-butyl hydroperoxide-induced damage in PC12 cells and D-galactose-induced neuronal cell loss in mice. BMC Complementary & Alternative Medicine 14:491  

5

Tseng TH, Shen CH, Huang WS, Chen CN, Liang WH, Lin TH, Kuo HC (2014) Activation of neutral-sphingomyelinase, MAPKs, and p75 NTR-mediating caffeic acid phenethyl ester-induced apoptosis in C6 glioma cells. Journal of Biomedical Science 21: 61  

6

Yang MY, Wang CJ, Chen NF, Ho WH, Lu FJ, Tseng TH* (2014) Luteolin enhances paclitaxel-induced apoptosis in human breast cancer MDA-MB-231 cells by blocking STAT3. Chemico-Biological Interactions 213, 60-68  

7

Y.J. Lee, W.L. Linb, N.F. Chen, S.K. Chuang, T.H. Tseng,(2013), Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice. European Journal of Medicinal Chemistry. 56, 361-367.  

8

W.L. Lin, Y.J. Lee, S.M. Wang, P.Y. Huang, T.H. Tseng*,(2012), Inhibition of cell survival, cell cycle progression , tumor growth and cyclooxygenase-2 activity in MDA-MB-231 breast cancer cells by camphorataimide . European Journal of Pharmacology. 680, 8-15.  

9

W.J. Lee, Y.R. Chen,(2010), Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells. Oncology Reports. 25, 583-591.  

10

W.L. Lin , W.H. Liang , Y.J.  Lee , S.K. Chuang , T.H. Tseng ,(2010), Antitumor progression potential of caffeic acid phenethyl ester involving p75NTR in C6 glioma cells. Chemico-Biological Interactions. 188, 607-615.  

11

T.H. Tseng , S.K. Chuang , C.C. Hu , Y.J. Lee , Y.C. Huang , C.W. Lin , (2010), The synthesis of morusin as a potent antitumor agent. Tetrahedron. 66, 1335-1340.  

12

W.J. Lee, F.J. Lu , S.F. Wang , Y.R. Chen , T.H. Tseng ,(2009), In vitro enhancement effect of humic acid on theprogressionof lung cancer cells. Chemico-Biological Interactions. 181, 463-471.  

13

T.H. Lin , F.J. Lu , T.H. Tseng , Y.F. Yin(2009), Enhancement of esculetin on arsenic trioxide-provoked apoptosis in human leukemia U937 cells. Chemico-Biological Interactions. 180, 61-68.  

14

E.S. Kao , T.H. Tseng , H.J. Lee , K.C. Chan , C.J. Wang ,(2009), Anthocyanin extracted from Hibiscus attenuate oxidized LDL-mediated foam cell formation involving regulation of CD36 gene. Chem Biol Interact. 2009 May 15;179(2-3):212-218. 179, 212-218.  

15

C.Y. Chu , H.J. Lee , C.F. Chu , Y.F. Yin , T.H. Tseng ,(2009), Protective effects of leaf extract of Zanthoxylum ailanthoides on oxidation of low-density lipoprotein and accumulation of lipid in differentiated THP-1 cells. Food and Chemical Toxicology. 47, 1265-1271.  

16

W.J. Lee , W.K. Chen , C.J. Wang , W.L. Lin , T.H. Tseng ,(2008), Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3-K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells. Toxicology and Applied Pharmacology. 226, 178-191.  

17

E.S. Kao , C.J. Wang , W.L. Lin , C.Y. Chu , T.H. Tseng ,(2007), Effect of polyphenols derived from fruit of Crataegus pinnatifida on cell transformation, dermal edema and skin tumor formation by phorbol ester application. Food and Chemical Toxicology. 45, 1795-1804.

 
 
   
B. 研討會論文  
1 Antioxidative and anti-inflammatory activities of polyphenolic extract from sugarcane juice of Saccharum sinenesis and its protective role against CCl4-induced hepatic damage in mice. 31屆生物醫學聯合學術年會,台灣(2016)  
2 Anti-heptic fibrosis potential of Dendrobium phenanthrenequinone derivatives. 30屆生物醫學聯合學術年會,台灣(2015)  
3 Extract of Wedelia chinesis Inhibits LPS/IFN-γ-Induced C6 Astrocytoma Cell Activation and Protects Against Inflammation-Mediated Differentiated PC12 Neuronal Cell Injury. 28屆生物醫學聯合學術年會,台灣(2013)  
4 Extract of Morus australis roots inhibits tumor promoter 12-O-tetradecanoylphorbol- 13 acetate -induced transformation of epidermal JB6 Cl41 cells. 28屆生物醫學聯合學術年會,台灣(2013)  
5 Morusin, a prenylated flavonoid, inhibits tumor promoter- induced transformation in JB6 cells. Biennial Meeting of Society for Free Radical Research Asia. (2013)  
6 Morusin Inhibits Invasive Growth in SK-Hep-1 Hepatoma Cells.第27屆生物醫學聯合學術年會,台灣(2012)  
7 Protective effect of polyphenolic extracts of Wedelia chinesis on beta-amyloid-induced oxidative stress in SH-SY5Y human neuroblastoma cells. 2011國際食品保健因子大會,台灣(2011)  
8 Protective Effect of Polyphenolic Extract of Wedelia chinesis on tert-Butyl hydroperoxide-induced Cytotoxicity in PC12 Neuroblastoma Cells.第26屆生物醫學聯合學術年會,台灣(2011)  
9 Protective Effect of Polyphenolic Extract of Wedelia chinesis on tert-Butyl hydroperoxide-induced Cytotoxicity in PC12 Neuroblastoma Cells.第26屆生物醫學聯合學術年會,台灣(2011)  
10 Augmentation of Luteolin on Paclitaxel-induced Apoptosis in Human Breast Cancer MDA-MB-231 Cells.第26屆生物醫學聯合學術年會,台灣(2011)  
11 Apigenin inhibits proliferation of MDA-MB-231 breast cancer cells in vitro and in vivo involving histone H3 acetylation mediated G2/M arrest.第25屆天然藥物研討會,台灣(2010)  
12 Inhibitory Effect Of Caffeic Phenethyl Ester On Invasion Of C6 Glioma Cells. 第25屆生物醫學聯合學術年會,台灣(2010)  
13 Luteolin-induced Apoptotic Death of Leukemia Cell Involving JNK Activation and Histone acetylation. 第24屆生物醫學聯合學術年會,台灣(2009)  
14 Apigenin Inhibits HGF/SF-Dependent Invasive Growth In Mda-Mb-231 Cells.第23屆生物醫學聯合學術年會,台灣(2008)